Description
Product Characteristics: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding, this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS.,ESYT2,CHR2SYT,E-Syt2,FAM62B,Cell Biology & Developmental Biology,ESYT2
Target Information: May play a role as calcium-regulated intrinsic membrane protein